| In een zevental cases dienen we in Sherlock Holmes: Crimes and Punishments moordzaken op te lossen, waarbij de beloning bestaat uit het verkrijgen van de volgende achievements. 
Aye Aye, Captain!	15Finish Black Peter case.
 
 Perfectionist	130
 Collect all possible in-game achievements.
 
 Dog-fancier	30
 Interact with Toby in every case.
 
 Off the Rails!	15
 Finish Train case.
 
 Blood and Ice	15
 Finish Blood Bath case.
 
 Vox populi, vox Dei	15
 Finish Abbey Grange case.
 
 A Deadly Flower	15
 Finish Kew Gardens case.
 
 Guilty Brotherhood	15
 Finish Half Moon case.
 
 Their Crimes, Your Punishments	30
 Complete the game.
 
 Bruiser	30
 Beat Cairns in a fight.
 
 Sharpshooter	30
 Disarm Mexican by shooting the gun from his hand.
 
 Raider of the Tombs	30
 Retrieve the Golden Knife from the ancient temple of Mithras.
 
 Hold your Herrings, Captain!	30
 Save Crocker from committing suicide.
 
 Suicide is Not an Option!	30
 Prevent Miss White from suicide.
 
 Haunted House	30
 Catch the thieves at Notting Hill Manor.
 
 Child's Play!	30
 Finish 25 mini games and puzzles without skipping.
 
 Elementary!	30
 Finish 35 mini games and puzzles without skipping.
 
 My Grey Matters	70
 Finish 45 mini games and puzzles without skipping.
 
 I Never Guess	70
 Reach 6 correct conclusions for all 6 cases.
 
 A Complex Mind	70
 Reach all possible conclusions in the game.
 
 A Man of Character	70
 Receive maximum personality ranking.
 
 Keen Observer	30
 Finish 15 "Character Observations" without skipping.
 
 A Methodical Man	70
 Gather 26 Character Portraits.
 
 I Never Fail	70
 Finish 10 Dialogue QTEs without a failure.
 
 An Omnivorous Reader	30
 Receive 3 messages from those whom you condemned or absolved.
 
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